Pigment research has played an important role in the connection between progress, genes and the development of chemistry. The application of pigmentation as a visible phenotypic marker has led to over 100 years of intensive research on shade-cover stresses in laboratory rats, thus creating an impressive record of candidate genes and knowledge of the developing systems responsible for phenotypic outcomes . Coat shade stress in laboratory rats has served as a leading model for learning the action of genes in a wide range of biological processes), leading to a wealth of information about genes involved in pigments and their development. communications. Because the chemistry of melanin-based pigments is highly conserved in vertebrates, a deep understanding of rabbit shade cover genes translates easily and directly into testable concepts for learning the molecular reasons for pigment difference in organic vertebrate communities ( Bennett and Lamoreux, 2003). In particular, selective forces such as crypsis, aposematism, thermoregulation and sexual signaling determine the difference in both pigments and shadow pattern. Therefore, pigment phenotypes in organic communities represent an ideal opportunity to learn the inherited reasons for broad phenotypic range and transformative change. of pigments has played a fundamental role in the fields of genes, growth and progress. With the growth of different stresses in rabbits, pigment phenotypes were readily available for research, and much of our information on the pigment procedure subsequently came from research on these laboratory rats. Then, in 1915, Haldane published the first research on hereditary linkage in vertebrates, establishing a link between the pink-eye dilution locus and the albino locus in the rabbit. Midway through the article several concerns about the procedure of transformative change: (1) Are changes in planning or regulatory areas differentially responsible for flexible morphology? (2) are flexible stresses generally prominent or recessive? and (3) are the same genes responsible for identical flexible phenotypes? Recent success in determining the heritable reasons for pigment difference in vertebrate organic communities provides additional, and sometimes surprising, insight into these concerns. Mutations in both programming and regulatory areas have been recognized and linked to flexible differences for a wide range of characteristics in a variety of systems, but the relative presence of programming versus regulatory stresses in the production of a wide morphological range remains unknown. recognized such stresses in cis-regulatory elements .