Medical and experimental research is important to society and has helped cure diseases, cancer, and other medical conditions for humans. But only if the experiments must be ethical and the experiment participant must have the right to choose whether to continue in the experiment or in the research. In today's world of medicine it would be very difficult for science and the community at large to accept any research or treatment similar to what Nazi doctors caused the deaths of thousands of individuals tested and subjected to this research and developments. The history of unethical research created the framework of the “Nuremberg Code” and the “Declaration of Helsinki,” the Belmont Report to protect and avoid painful and unnecessary deaths for humans and animals. Research must be useful and help cure diseases and must bring value to people. These experiments and tests on humans and animals are extremely inhumane. These researches are extremely risky and possible harm to the person and some extreme experiences could cause infinite effects on them. One of the most interesting articles on this research is “Ethics in Clinical Research, the History of Human Subject Protection, and the Implementation of Ethical Standards in Practice” by David Perlman, Ph.D. and Glaxo Smith Kline. The article talks about ethical regulation and past practices that were inhumane to people. There are different research methods that can be conducted if there is proper technology and guidance with advanced technology, human could test the subject on other items, such as tree, plant and so on. However, after reviewing these articles, it has become difficult to understand the real reason behind these experiments is conducting and testing. Discuss the “Nuremberg Code”…half of the article…the “natural progression of syphilis”. The “data collection” experiment was exposed by the “New York Times” in 1972. Originally the research was only supposed to last a few months, however the data was very important to the doctor so they continued the experiment. However, in 1940 the researcher refused to administer penicillin to men. The main purpose of this research was to collect data, the individuals chosen to participate are mainly uneducated and do not have a good living status. These men come from the state of Alabama, in the city of Tuskegee. The researcher refused to provide “penicillin” treatment to the men. This action represents unethical behavior for the observed individual. Even those that do not harm the individual, but denying treatment when it is available is considered unethical for the researcher.