I am a basic biochemist and am interested in the events that take place in cancer biology at the molecular level. I found it interesting that RNA biology and underlying events play a crucial role in the above mentioned. My primary goal is to understand the basic and fundamental mechanisms of protein synthesis and determine how these mechanisms contribute to both normal and disease states, particularly celiac disease and cancer. The main mechanism for regulating protein synthesis is in the initiation phase. To initiate translation of a messenger RNA it is necessary to recruit the ribosome to the mRNA and position it on the initiator codon (AUG). The main mechanism of these processes is called the cap/scanning model whereby the cap binding protein binds the 5' end of the mRNA, 7 methyl guanosine triphosphate, and recruits the translation machinery including the 40S ribosome. The ribosome, in turn, migrates or explores along the 5' leader until it encounters an AUG in the appropriate context. An alternative and less well-known mechanism is the recruitment of the ribosome by the 5' leader. Say no to plagiarism. Get a tailor-made essay on "Why Violent Video Games Shouldn't Be Banned"? Get an original essay. These regions downstream of the cap structure are called internal ribosomal entry sites (IRES). IRESs have been best studied in various clinical conditions and in a subset of viruses including poliovirus and hepatitis C. To date, only a small percentage of eukaryotic mRNAs have been shown to contain an IRES and the mechanism and function of these eukaryotic IRES is not well studied. understood. Conditions that inhibit or reduce cap-dependent translation are proposed to maintain or enhance IRES-dependent translation. These same conditions contribute to cancer. My ultimate research goal is to identify IRESs in mRNAs that encode proteins essential to the etiology that contribute to carcinogenesis (Aurora A Kinase). Furthermore, I am interested in examining the regulation (or misregulation) of the above IRESs, in part by identifying intracellular signaling pathways that potentially lead to post-translational modification of specific RNA-binding proteins in culture, as well as to creation of transgenic animals that can be used both for my research and for future generations. Celiac disease (CD) is a chronic immune-mediated disease triggered by the ingestion of gluten in genetically predisposed individuals. Before activating the immune system, gluten peptides are transferred from the epithelial barrier to the lamina propria of the mucosa, where they are deamidated by transglutaminase2 of the intestinal tissue. When it comes to celiac disease in India, research focuses mainly on the clinical aspect rather than the pharmacological one. Numerous journals have been published, but most of them have reported clinical case studies. This is not a retrospective study published to date and the number of stakeholders or the underlying facts have not yet been brought to light for the benefit of the public..