Despite the numerous possible life-long consequences following an allogeneic organ transplant, such as graft rejection, side effects of long-term immunosuppression and unquantifiable risk of disease transmission, many patients with organ failure are currently still in desperate need of a new, healthy organ to have a second chance at life. Therefore this essay will discuss bioartificial organs as the future of organ transplantation. Say no to plagiarism. Get a tailor-made essay on "Why Violent Video Games Shouldn't Be Banned"? Get an original essayThe Ott Laboratory for Organ Engineering and Regeneration has taken a leading role in the fields of regenerative medicine and biotechnology by suggesting a method that minimizes the risk of rejection and the need for immunosuppression following an organ transplant organs. Dr. Harald Ott, the company's founder, had the idea of ​​infusing differentiated, patient-specific cells from human pluripotent stem cells into decellularized donor organ scaffolds, generating a "customized" organ for transplantation. The new bioartificial organ will then be inserted into a bioreactor, where it will remain until complete maturation, before being implanted in the patient. Despite being in the early development stage, many successful experiments in smaller animals have demonstrated that this technology is applicable as an alternative source for organ transplantation. First, experiments on RNU rats have demonstrated that engineered bioartificial intestines can regain basic and life-sustaining functions, such as glucose and fatty acid uptake in vivo. Second, Dr. Ott and his team's bioengineered kidney has been shown to partially restore the basic physiological functions of a native kidney, such as macromolecular sieving, glucose and electrolyte reabsorption. The successes of both experiments, therefore, undeniably serve as strong affirmations that this technology may one day be applicable and beneficial to humans. However, given that this technology has only recently been transformed by a proof of principle, further improvements and many more years of development would be needed to create a bioartificial organ with 100% functionality that will be safe and effective for humans. The current technology of using acellular organ scaffolds and patient-derived cells for organ regeneration is still in its early stage of development and therefore requires funding to fuel progress and make this technology accessible to all. The technology that uses Oct3/4, Sox2, c-Myc and Klf43 to transform human somatic cells into pluripotent stem cells and from them create all types of human cells with self-renewal capabilities, makes this an ever-expanding field with infinite potential potential. Specifically, this method of using stem cells to create patient-specific organ transplants will revolutionize the field of regenerative medicine and solve many existing problems caused by the current organ transplant method listed above, making this company a long-term investment very promising term. Keep in mind: this is just one example. Get a custom paper from our expert writers now. Get a Custom Essay Finally, with the endless applications and possibilities of technology such as personalized multi-organ transplantation, cell therapy, tissue regeneration for injuries, and graft transplantation, I firmly believe that technology,3650107/